| Haptoglobin genotypes and refractory hypertension in type 2 diabetes mellitus patients. | |
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MedLine Citation:
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PMID: 22011804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: It has been suggested that haptoglobin polymorphism may influence the pathogenesis of microvascular and macrovascular complications in diabetic patients. OBJECTIVE: This cross sectional study was carried out to investigate the existence or not of an association between haptoglobin genotypes and prevalence of ischemic cardiovascular events (stable angina, unstable angina and acute myocardial infarction), systemic arterial hypertension, refractory hypertension, obesity and dyslipidemia in 120 type-2 diabetes mellitus patients followed up at Hospital de Clínicas da UNICAMP in Campinas, São Paulo state, southeastern Brazil. METHODS: Haptoglobin genotyping was performed by allele-specific polymerase chain reactions. The frequencies of the haptoglobin genotypes were compared with the presence/absence of cardiovascular disease, systemic arterial hypertension, refractory hypertension, obesity and dyslipidemia; systolic and diastolic blood pressure measurements; plasma levels of glucose, cholesterol (total, high density lipoprotein-HDL and low density lipoprotein-LDL) and triglycerides; and serum creatinine levels. RESULTS: Although no association between haptoglobin genotype and the presence of cardiovascular disease could be identified, we found a significant excess of patients with Hp2-1 genotype among those with refractory hypertension, who also had higher systolic and diastolic blood pressure, and total and LDL cholesterol levels. CONCLUSION: Our results suggest that type-2 diabetes mellitus patients with the Hp2-1 genotype may have higher chances of developing refractory hypertension. Further studies in other diabetic populations are required to confirm these findings. |
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Authors:
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Vânia Pereira Albuquerque Wobeto; Paula da Cunha Pinho; José Roberto M Souza; Tânia Regina Zaccariotto; Maria de Fátima Zonati |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-21 |
Journal Detail:
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Title: Arquivos brasileiros de cardiologia Volume: - ISSN: 1678-4170 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: - |
Other Details:
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Languages: ENG; POR Pagination: - Citation Subset: - |
Affiliation:
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Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Unicamp, Campinas, SP, Brasil. |
Vernacular Title:
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Genótipos de haptoglobina e hipertensão refratária em pacientes com diabete melito tipo 2. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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