Document Detail

'Haptoglobin concentrations in preterm and term newborns'.
MedLine Citation:
PMID:  21252963     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns.
STUDY DESIGN: HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon-Mann-Whitney test was used for comparisons.
RESULT: HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033).
CONCLUSION: HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis.
S Chavez-Bueno; J A Beasley; J M Goldbeck; B C Bright; D J Morton; P W Whitby; T L Stull
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-01-20
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  31     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-29     Completed Date:  2011-11-21     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  500-3     Citation Subset:  IM    
Department of Pediatrics, Section of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
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MeSH Terms
Bacteremia / blood*,  diagnosis,  epidemiology
Biological Markers / blood
Cohort Studies
Disease Susceptibility / blood
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Haptoglobins / analysis*
Infant, Newborn
Infant, Premature / blood*
Intensive Care Units, Neonatal
Prospective Studies
Reference Values
Risk Assessment
Sensitivity and Specificity
Term Birth / blood*
Reg. No./Substance:
0/Biological Markers; 0/Haptoglobins
Comment In:
J Perinatol. 2012 Apr;32(4):312; author reply 313   [PMID:  22460602 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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