| 'Haptoglobin concentrations in preterm and term newborns'. | |
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MedLine Citation:
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PMID: 21252963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns. STUDY DESIGN: HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon-Mann-Whitney test was used for comparisons. RESULT: HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033). CONCLUSION: HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis. |
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Authors:
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S Chavez-Bueno; J A Beasley; J M Goldbeck; B C Bright; D J Morton; P W Whitby; T L Stull |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-01-20 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 31 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-29 Completed Date: 2011-11-21 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 500-3 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Section of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Susana-Chavez-Bueno@ouhsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteremia
/
blood*,
diagnosis,
epidemiology Biological Markers / blood Cohort Studies Disease Susceptibility / blood Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Haptoglobins / analysis* Humans Incidence Infant, Newborn Infant, Premature / blood* Intensive Care Units, Neonatal Male Prospective Studies Reference Values Risk Assessment Sensitivity and Specificity Term Birth / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Haptoglobins |
| Comments/Corrections | |
Comment In:
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J Perinatol. 2012 Apr;32(4):312; author reply 313
[PMID:
22460602
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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