Document Detail


Haptoglobin phenotype correlates with the extent of cerebral deep white matter lesions in hypertensive patients.
MedLine Citation:
PMID:  20158468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral white matter lesions (WMLs), due to small vessel disease, can be regarded as an early "silent" sign of hypertensive cerebral end-organ damage. As haptoglobin (Hp) phenotype has earlier been associated with symptomatic vascular disease, we now examined the relationship between Hp phenotype and asymptomatic cerebral small vessel disease, manifested by deep and periventricular WMLs, in hypertensive patients. We determined Hp phenotype using starch gel electrophoresis in 152 hypertensive patients without symptomatic vascular disease. We found 26 (17.1%) Hp1-1, 89 (58.6%) Hp2-1 and 37 (24.3%) Hp2-2. Volumes of deep and periventricular WMLs were quantitatively measured on brain MR images. Patients were ranked in 5 categories according to ascending WMLs volumes. Compared to Hp2-2, Hp1-1 was associated with larger deep WMLs volumes when adjusted for age, gender, brain volume, 24-hour mean arterial pressure, duration of hypertension and previous antihypertensive treatment (ordinal regression analysis, OR 2.77, 95%CI 1.08-7.11, p=0.034). No association was found between Hp phenotype and periventricular WMLs. Hp1-1 phenotype correlates with the extent of hypertensive deep white matter damage. One of the possibilities is that this is related to lower regenerating power against endothelial injury in Hp1-1 individuals.
Authors:
Julie Staals; Léon H G Henskens; Joris R Delanghe; Robert J van Oostenbrugge; Alfons G Kessels; Abraham A Kroon; Peter W de Leeuw; Jan Lodder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current neurovascular research     Volume:  7     ISSN:  1875-5739     ISO Abbreviation:  Curr Neurovasc Res     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-22     Revised Date:  2011-06-07    
Medline Journal Info:
Nlm Unique ID:  101208439     Medline TA:  Curr Neurovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Maastricht University Medical Centre, Maastricht, the Netherlands. j.staals@mumc.nl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Pressure / physiology
Cerebral Cortex / pathology*
Cerebrovascular Circulation / physiology
Female
Haptoglobins / genetics*,  metabolism
Humans
Hypertension / genetics*,  pathology*,  physiopathology
Magnetic Resonance Imaging / methods
Male
Middle Aged
Nerve Fibers, Myelinated / pathology*
Odds Ratio
Phenotype*
Regression Analysis
Retrospective Studies
Chemical
Reg. No./Substance:
0/Haptoglobins

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