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Hapten Facilitates Food Allergen-Related Intestinal Hypersensitivity.
MedLine Citation:
PMID:  22814364     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Haptens can bind to proteins to elicit antigenicity. Whether haptens play a role in the pathogenesis of food allergy remains to be investigated. This article aims to elucidate the role a hapten plays in food antigen-related T helper 2 (Th2) pattern inflammation in the intestine. METHODS:: The effect of trinitrobenzene sulfonic acid (TNBS; as a hapten) on the properties of dendritic cells was assessed by a cell culture model. BALB/c mice were sensitized with a mixture of TNBS and ovalbumin (OVA; as a model antigen). Intestinal Th2 response, OVA-specific immunoglobulin E and histamine were analyzed with the mouse model. In addition to the infiltration of the intestinal inflammatory cells, cytokine expression profiles were determined. RESULTS:: TNBS increased the expression of T-cell immunoglobulin and mucin domain-4 and CD80 and decreased the levels of interleukin-12 in dendritic cells. Higher serum levels of OVA-specific immunoglobulin E, histamine expression and skewed antigen-specific Th2 polarization in the intestinal tissue were detected in mice sensitized with TNBS + OVA as compared with those treated with either OVA or TNBS alone. In addition, the TNBS-OVA-treated mice also showed an increased number of inflammatory cells, high levels of interleukin-4 and a decreased expression of interferon-γ in the lamina propria mononuclear cells. CONCLUSIONS:: Hapten TNBS can facilitate the initiation of food antigen-related Th2 pattern inflammation, such as food allergy, in the intestine.
Authors:
Zhi-Qiang Liu; Peng-Yuan Zheng; Ping-Chang Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gastroenterology (Z-QL, P-YZ), the Second Hospital, Zhengzhou University, Zhengzhou, China; and Department of Pathology and Molecular Medicine (Z-QL, P-CY), McMaster University, Hamilton, Ontario, Canada.
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