| Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts. | |
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MedLine Citation:
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PMID: 16755277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipoprotein lipase (LPL) hydrolyzes circulating triglycerides (TGs). We previously showed that 3'-end haplotypes in the LPL gene influence atherosclerosis and insulin resistance. This study asked whether these LPL haplotypes influence response to lipid-lowering therapy among 829 subjects from the Post-Coronary Artery Bypass Graft trial. Lipid profiles were obtained at baseline and 4-5 years after treatment with lovastatin. Haplotypes were based on 12 SNPs. The fourth most frequent haplotype, 12-4, was associated with a decreased increment in high-density lipoprotein-cholesterol (HDL-C) following treatment. Haplotypes 12-6, 12-7 and 12-8 were each associated with increased HDL-C response to therapy, and haplotype 12-2 with decreased TG response. The most common haplotype, 12-1, was protective against graft worsening or occlusion. Haplotype 12-4 reduced HDL-C response to lovastatin, possibly consistent with our prior observations of this haplotype as predisposing to coronary artery disease. LPL may influence atherosclerosis risk through pleiotropic effects on each aspect of the metabolic syndrome. |
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Authors:
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M O Goodarzi; K D Taylor; M T Scheuner; H J Antoine; X Guo; P K Shah; J I Rotter |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-06-06 |
Journal Detail:
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Title: The pharmacogenomics journal Volume: 7 ISSN: 1470-269X ISO Abbreviation: Pharmacogenomics J. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-06-20 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101083949 Medline TA: Pharmacogenomics J Country: United States |
Other Details:
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Languages: eng Pagination: 66-73 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA 9048, USA. mark.goodarzi@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alleles Anticholesteremic Agents / therapeutic use* Atherosclerosis / drug therapy*, genetics*, pathology Blood Pressure / physiology Cholesterol, HDL / genetics* Cohort Studies Coronary Artery Bypass* Coronary Restenosis / drug therapy*, genetics*, pathology Disease Progression Female Genotype Haplotypes Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Insulin Resistance / genetics Lipoprotein Lipase / genetics* Male Mexican Americans Middle Aged Polymorphism, Single Nucleotide Reverse Transcriptase Polymerase Chain Reaction |
| Grant Support | |
ID/Acronym/Agency:
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HL-28481/HL/NHLBI NIH HHS; HL-69757/HL/NHLBI NIH HHS; RR000425/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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