| Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. | |
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MedLine Citation:
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PMID: 20235788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To analyze the association of haplotypes of the adrenergic system with essential hypertension and with the blood pressure response to beta-blockers. MATERIALS & METHODS: In 1112 never-treated essential hypertension patients and 203 normotensive controls, tightly linked SNPs of beta-adrenergic receptors (ADRB1 - Ser49Gly and Arg389Gly; ADRB2 - Cys19Arg, Gly16Arg and Gln27Glu) and the G-protein beta3-subunit (GNB3 - A3882C, G5249A and C825T) were genotyped. Association of haplotypes with essential hypertension and with the blood pressure response to atenolol 50 mg twice daily in a subgroup of essential hypertension patients (n = 340) was evaluated (Haploview 3.2). RESULTS: No SNPs or haplotypes were associated with essential hypertension. In females only, GNB3 SNPs and haplotypes were associated with the blood pressure response (p < 0.05). CONCLUSION: Our study confirmed the sex-specific association of GNB3 with the blood pressure response to atenolol with no substantial advantage of the analysis of haplotypes over SNPs. |
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Authors:
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Fabiana Filigheddu; Giuseppe Argiolas; Simona Degortes; Roberta Zaninello; Francesca Frau; Silvia Pitzoi; Emanuela Bulla; Patrizia Bulla; Chiara Troffa; Nicola Glorioso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacogenomics Volume: 11 ISSN: 1744-8042 ISO Abbreviation: Pharmacogenomics Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-18 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897350 Medline TA: Pharmacogenomics Country: England |
Other Details:
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Languages: eng Pagination: 319-25 Citation Subset: IM |
Affiliation:
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Chair of Emergency, University of Sassari Medical School and Hypertension & Cardiovascular Prevention Center, Viale S Pietro 8, 07100 Sassari, Italy. ffiligheddu@uniss.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Adult Aged Atenolol / pharmacology Base Sequence Blood Pressure / drug effects*, genetics* Case-Control Studies DNA Primers / genetics Female Genetic Association Studies Haplotypes* Heterotrimeric GTP-Binding Proteins / genetics* Humans Hypertension / drug therapy*, genetics*, physiopathology Middle Aged Pharmacogenetics Polymorphism, Single Nucleotide Receptors, Adrenergic, beta-1 / genetics* Receptors, Adrenergic, beta-2 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/ADRB1 protein, human; 0/Adrenergic beta-Antagonists; 0/DNA Primers; 0/G-protein beta3 subunit; 0/Receptors, Adrenergic, beta-1; 0/Receptors, Adrenergic, beta-2; 29122-68-7/Atenolol; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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