| Haploidentical transplantation in patients with acquired aplastic anemia. | |
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MedLine Citation:
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PMID: 23292235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Haploidentical SCT (haplo-SCT) has been considered a therapeutic option in patients with acquired severe aplastic anemia (SAA) failing at least one course of immune suppressive therapy with antithymocyte globulin and lacking an HLA-matched related or unrelated donor. The platforms of both ex vivo T-cell-depleted and unmanipulated grafts have been explored in children and adults. Overall, the primary objective of a stable haploidentical hematopoietic engraftment with a low rate of GVHD is unmet in a significant proportion of patients undergoing haplo-SCT for SAA. Haploidentical transplants for refractory SAA should be performed in a specialist center with major experience in hematopoietic SCT procedures and preferably performed within the framework of a local clinical protocol designed specifically to address the prevention of graft rejection and GVHD.Bone Marrow Transplantation advance online publication, 7 January 2013; doi:10.1038/bmt.2012.231. |
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Authors:
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F Ciceri; M T Lupo-Stanghellini; E T Korthof |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-07 |
Journal Detail:
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Title: Bone marrow transplantation Volume: - ISSN: 1476-5365 ISO Abbreviation: Bone Marrow Transplant. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hematology and BMT Unit, EBMT CIC 813, San Raffaele Scientific Institute, Milano, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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