| Hantavirus outbreak associated with laboratory rats in Yunnan, China. | |
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MedLine Citation:
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PMID: 20380897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages. |
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Authors:
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Yunzhi Zhang; Hailin Zhang; Xingqi Dong; Junfa Yuan; Huajun Zhang; Xinglou Yang; Peng Zhou; Xingyi Ge; Yan Li; Lin-Fa Wang; Zhengli Shi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-07 |
Journal Detail:
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Title: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases Volume: 10 ISSN: 1567-7257 ISO Abbreviation: Infect. Genet. Evol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101084138 Medline TA: Infect Genet Evol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 638-44 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Laboratory / virology* Base Sequence China / epidemiology Disease Outbreaks Disease Vectors Hantaan virus / classification, genetics* Hemorrhagic Fever with Renal Syndrome / epidemiology*, genetics* Humans Male Molecular Sequence Data Phylogeny RNA, Viral / analysis Rats Recombination, Genetic Sequence Analysis, DNA Universities Young Adult Zoonoses* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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