Document Detail


Hanja (Ideogram) alexia and agraphia in patients with semantic dementia.
MedLine Citation:
PMID:  19967597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Posterior fusiform gyrus (BA 37) is responsible for Hanja (ideogram) alexia in stroke patients. Patients with semantic dementia (SD) have lesions in the basal temporal area. The close proximity in these two lesions and the fact that reading ideograms requires holistic processing as is necessary in recognition of objects, suggests a possibility that ideogram alexia/agraphia may occur in patients with SD. We established and carried out Hanja and Hangul (phonogram) reading/writing tasks on six SD patients and nine Alzheimer's disease (AD) patients as control to see if these two patient groups show dissociation in the two sets of tests. SPM analysis was performed on the SD patients' PET images to look for any dysfunctions in the posterior fusiform gyrus. The SD patients manifested Hanja alexia/agraphia whereas Hangul reading/writing ability was relatively preserved. There were group differences between SD and AD in the Hanja tasks but not in the Hangul tasks. The SPM analysis revealed no hypometabolism in the posterior fusiform gyrus, but only in the middle and the anterior part of the temporal gyrus. Dysfunction in the middle temporal gyrus (BA 21) may have disrupted the temporal lobe connections preventing the function of the posterior fusiform gyrus.
Authors:
Mee Kyung Suh; Eun-Joo Kim; Byung Hwa Lee; Sang Won Seo; Juhee Chin; Sue J Kang; Duk L Na
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Publication Detail:
Type:  Journal Article     Date:  2009-12-04
Journal Detail:
Title:  Neurocase     Volume:  16     ISSN:  1465-3656     ISO Abbreviation:  Neurocase     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-06-29     Revised Date:  2011-03-01    
Medline Journal Info:
Nlm Unique ID:  9511374     Medline TA:  Neurocase     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-56     Citation Subset:  IM    
Affiliation:
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Agraphia / complications,  physiopathology*,  radionuclide imaging
Alzheimer Disease / physiopathology,  radionuclide imaging
Brain Mapping
Disability Evaluation
Dominance, Cerebral / physiology
Dyslexia / complications,  physiopathology*,  radionuclide imaging
Female
Frontotemporal Lobar Degeneration / complications,  physiopathology*,  radionuclide imaging
Functional Laterality / physiology
Humans
Language
Language Tests
Male
Middle Aged
Neuropsychological Tests
Pattern Recognition, Visual / physiology*
Photic Stimulation
Positron-Emission Tomography
Predictive Value of Tests
Reading
Republic of Korea
Symbolism
Temporal Lobe / pathology,  physiopathology*,  radionuclide imaging
Visual Cortex / pathology,  physiopathology,  radionuclide imaging
Visual Pathways / pathology,  physiopathology*,  radionuclide imaging

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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