Document Detail


Handwriting in patients with Parkinson disease: Effect of l-dopa and stimulation of the sub-thalamic nucleus on motor anticipation.
MedLine Citation:
PMID:  21339012     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence.
Authors:
Christel Bidet-Ildei; Pierre Pollak; Sonia Kandel; Valérie Fraix; Jean-Pierre Orliaguet
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-19
Journal Detail:
Title:  Human movement science     Volume:  -     ISSN:  1872-7646     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8300127     Medline TA:  Hum Mov Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Laboratoire de Psychologie et NeuroCognition, CNRS UMR 5105, BP47, 38040 Grenoble Cedex 9, France; CeRCA, CNRS UMR 6234, 5, rue Théodore Lefebvre, 86000 Poitiers, France.
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