| Handedness, language dominance and aphasia: a genetic model. | |
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MedLine Citation:
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PMID: 3863155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple two-allele Mendelian model of the genetics of handedness is described and fitted to data in the literature. The model proposes that there are two alleles, D (dextral) and C (chance), the homozygous DD genotype producing only right-handers (directional asymmetry), the homozygous CC genotype producing a racemic mixture of 50% right-handers and 50% left-handers (fluctuating asymmetry), and the heterozygote, DC, being intermediate between the homozygotes and producing 25% left-handers, and 75% right-handers. It is also suggested that the true population incidence of left-handedness is 7.75%, deviations from this figure being due to either criterion shifts or selection biases. The same model is then fitted, by means of a number of minor conceptual extensions, to data from the literature on the relationship of handedness to language dominance, acute and permanent aphasia, and visual processing dominance. |
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Authors:
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I C McManus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychological medicine. Monograph supplement Volume: 8 ISSN: 0264-1801 ISO Abbreviation: Psychol Med Monogr Suppl Publication Date: 1985 |
Date Detail:
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Created Date: 1985-11-14 Completed Date: 1985-11-14 Revised Date: 2008-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8301104 Medline TA: Psychol Med Monogr Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1-40 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aphasia
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genetics* Brain Damage, Chronic / physiopathology Cerebral Cortex / physiopathology Dichotic Listening Tests Female Functional Laterality / physiology* Hand / physiology Humans Language* Male Models, Genetic* Phenotype Speech / physiology Twins Visual Perception / physiology |
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