Document Detail

Hand radiology characteristics of patients carrying the T(303)M mutation in the gene for matrilin-3.
MedLine Citation:
PMID:  16641049     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether the recently described hand osteoarthritis (HOA)-associated T(303)M mutation in the gene for matrilin-3 (MATN3) is associated with specific radiological changes on hand radiographs. METHOD: Standard hand radiographs from 26 HOA patients carrying the T(303)M missense mutation in the MATN3 gene (T(303)M patients) were compared with those from 52 HOA controls matched for sex, age, and clinical disease severity. Two blinded readers scored the radiographs, using the Verbruggen-Veys anatomical scoring system for the interphalangeal and metacarpophalangeal joints and the OARSI atlas scoring system for the first carpometacarpal (CMC1) joints. A scoring system based on the latter was used for the scaphoid-trapezoid-trapezoideum (STT) joints. RESULTS: No particular distinguishing features were found in the T(303)M patients and the prevalence of erosive and cystic changes was similar to the control group. As a group, however, the T(303)M patients had more severe thumb-base affection, particularly in the STT joint. Thus, definite radiological OA in both CMC1 and STT joints and higher STT scores compared with CMC1 were significantly more common in patients carrying the T(303)M mutation. Radiological scores for joint-space narrowing (CMC1 and STT) and osteophytes (STT) were also significantly higher in the T(303)M patients. CONCLUSION: Patients carrying the T(303)M mutation in the gene for matrilin-3 express a form of HOA that is radiologically indistinguishable from idiopathic HOA in individual patients but they have more severe thumb-base involvement, particularly in the STT joint. This is the first described genetic mutation that is associated with a common form of osteoarthritis.
G J Eliasson; G Verbruggen; S E Stefansson; T Ingvarsson; H Jonsson
Related Documents :
3958019 - Radiographic assessment in patellar instability and chondromalacia patellae.
15085509 - The occurrence of antibodies against chlamydia species in patients with monoarthritis a...
17715719 - Hemiarthroplasty for three- and four- part displaced fractures of the proximal humerus ...
9725309 - Sonography of achilles tendon xanthomas in patients with heterozygous familial hypercho...
12384919 - Uncoupling of type ii collagen synthesis and degradation predicts progression of joint ...
6869659 - Reconstruction of the anterior cruciate ligament using free tendon graft.
1035149 - Perioral dermatitis: etiology and treatment.
22645059 - Positive effect of eplerenone treatment on endothelial progenitor cells in patients wit...
20104459 - Evaluation of autonomic imbalance in patients with heart failure: a preliminary study o...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  35     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-04-27     Completed Date:  2006-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  138-42     Citation Subset:  IM    
Roentgen Domus Medica, Reykjavik, Iceland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
DNA / genetics*
Extracellular Matrix Proteins / genetics*
Genetic Markers
Hand Joints / radiography*
Metacarpophalangeal Joint / radiography
Middle Aged
Mutation, Missense*
Osteoarthritis / genetics*,  radiography*
Retrospective Studies
Severity of Illness Index
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Genetic Markers; 0/matrilin 3; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endothelin-1 serum levels correlate with MCP-1 but not with homocysteine plasma concentration in pat...
Next Document:  Systemic vasculitis associated with Fasciola hepatica infection.