Document Detail

Hand movements at 3 months predict later hemiplegia in term infants with neonatal cerebral infarction.
MedLine Citation:
PMID:  19863639     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to explore the predictive value of quantitative assessment of hand movements in 3-month-old infants after neonatal stroke. METHOD: Thirteen infants born at term (five females, eight males; mean gestational age 39.4wks, SD 1.19, range 37-41wks; mean birthweight 3240g, SD 203, range 2900-3570g) with neonatal arterial ischaemic cerebral infarction, and 13 healthy infants (mean gestational age 39.1wks, range 37-41wks, SD 1.26; mean birthweight 3190g, SD 259, range 2680-3490g) were enrolled in the study. The absolute frequency and the asymmetry of global hand opening and closing, wrist segmental movements, and independent digit movements were assessed from videotapes recorded at around 12 weeks. Neurological outcome was assessed when the infants were at least 18 months old using Touwen's neurological examination. RESULTS: Five of the 13 infants with neonatal stroke had normal neurological development, and eight had hemiplegia. Asymmetry of wrist segmental movements and the absolute frequency of independent digit movements were significantly different between infants with and without hemiplegia (p=0.006 and p=0.008, respectively). No differences were found in global hand movements. INTERPRETATION: We propose that the observed abnormalities of hand movements are the result of two different mechanisms: direct disruption of the corticospinal projection to the spinal cord, and altered modulation of the central pattern generators of general movements.
Andrea Guzzetta; Alessandra Pizzardi; Vittorio Belmonti; Antonio Boldrini; Marco Carotenuto; Giulia D'Acunto; Fabrizio Ferrari; Simona Fiori; Claudio Gallo; Paolo Ghirri; Eugenio Mercuri; Domenico Romeo; Maria Federica Roversi; Giovanni Cioni
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-10-23
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  52     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  767-72     Citation Subset:  IM    
Department of Developmental Neuroscience, Scientific Institute Stella Maris, Calambrone, Pisa, Italy.
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MeSH Terms
Brain / blood supply*,  physiopathology*
Brain Ischemia / epidemiology*,  physiopathology*
Gestational Age
Hand / physiopathology*
Hemiplegia / diagnosis*,  epidemiology*
Infant, Newborn
Movement Disorders / diagnosis,  epidemiology*,  physiopathology*
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
Comment In:
Dev Med Child Neurol. 2010 Aug;52(8):698   [PMID:  20059517 ]

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