Document Detail


Hand motor recovery after stroke: a transcranial magnetic stimulation mapping study of motor output areas and their relation to functional status.
MedLine Citation:
PMID:  12234089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The respective contributions of the stroke and undamaged hemispheres to motor recovery after stroke remains controversial. The aim of this article is to evaluate the relationship between location and size of cortical motor areas and outcome after stroke. Twelve controls and 12 stroke patients were studied. Hand cortical motor output areas were determined using transcranial magnetic stimulation. Motor-evoked potentials were recorded simultaneouslyfrom both hands. Functional motor abilities were evaluated using well-validated measures. Surface area, weighted surface area, and center of gravity of motor output areas were calculated. Different patterns of motor output areas to the paretic band were observed; there was no motor output from the stroke hemisphere in patients with poor outcome, contrasting to large motor output area in the stroke hemisphere in patients with good outcome, regardless of infarct size or location. A significant correlation was found between measures of motor outcome in the stroke-affected upper extremity and both the surface area and weight of the central motor output area in the stroke hemisphere. No ipsilateral motor response was obtained after stimulation of either hemisphere. These data support an association between preservation of cortical motor output area to the paretic hand in the stroke hemisphere and good motor outcome.
Authors:
Eric P Bastings; Jason P Greenberg; David C Good
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurorehabilitation and neural repair     Volume:  16     ISSN:  1545-9683     ISO Abbreviation:  Neurorehabil Neural Repair     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-17     Completed Date:  2003-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100892086     Medline TA:  Neurorehabil Neural Repair     Country:  United States    
Other Details:
Languages:  eng     Pagination:  275-82     Citation Subset:  IM    
Affiliation:
Division of Neuropharmacological Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain Mapping
Disability Evaluation
Electromyography
Evoked Potentials / physiology
Female
Functional Laterality
Hand
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motor Cortex / physiopathology*
Motor Skills
Stroke / physiopathology,  rehabilitation*
Transcranial Magnetic Stimulation / diagnostic use
Grant Support
ID/Acronym/Agency:
1P01HD35955-01A1/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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