| Hand-foot syndrome with sclerodactyly-like changes in a patient treated with capecitabine. | |
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MedLine Citation:
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PMID: 18360124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Capecitabine, a fluoropyrimidine carbamate with antineoplastic activity, is an oral agent that was developed as a prodrug of 5-fluorouracil and is used in the treatment of metastatic colorectal and breast cancers. Multiple cutaneous adverse effects had been described with the use of this drug, but to our knowledge, specific association with capecitabine and hand-foot syndrome with sclerodactyly-like changes has been described only once. We report a patient with a colon adenocarcinoma who presented with hand-foot syndrome, with sclerodactyly-like changes induced by capecitabine. |
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Authors:
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Felicidade Trindade; Rosario Haro; Maria Carmen Fariña; Luis Requena |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 30 ISSN: 1533-0311 ISO Abbreviation: Am J Dermatopathol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: United States |
Other Details:
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Languages: eng Pagination: 172-3 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Hospital dos Capuchos, Lisbon, Portugal. felicidade.trindade@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy,
secondary Administration, Oral Biopsy, Needle Deoxycytidine / adverse effects, analogs & derivatives*, therapeutic use Dose-Response Relationship, Drug Fluorouracil / adverse effects, analogs & derivatives*, therapeutic use Follow-Up Studies Hand Dermatoses / chemically induced*, pathology Humans Immunohistochemistry Liver Neoplasms / drug therapy, secondary Male Middle Aged Scleroderma, Localized / chemically induced*, pathology* Severity of Illness Index Sigmoid Neoplasms / drug therapy, pathology Syndrome |
| Chemical | |
Reg. No./Substance:
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154361-50-9/capecitabine; 51-21-8/Fluorouracil; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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