Document Detail

Halting the natural history of hepatitis B viral infection: a paradigm shift.
MedLine Citation:
PMID:  17701844     Owner:  NLM     Status:  MEDLINE    
The 2007 American Association for the Study of Liver Diseases (AASLD) practice guidelines for managing chronic hepatitis B virus (HBV) infection recommend pharmacologic therapy for patients with alanine aminotransferase (ALT) activity higher than 2 times the upper limit of normal and serum HBV DNA concentration higher than 20,000 IU/mL. Findings reported over the past several years, however, indicate that HBV infection associated with ALT activity and serum HBV DNA concentrations below these treatment thresholds can progress to serious liver disease, such as cirrhosis or hepatocellular carcinoma. These findings suggest that these treatment thresholds may be too conservative. Moreover, emerging data suggest that, in some patient populations, the appropriate goal of therapy may be sustained suppression of HBV DNA with maintenance antiviral therapy. A satellite symposium conducted during the 57th Annual Meeting of the AASLD in Boston, Massachusetts, presented new findings relative to the course of HBV infection.
Robert P Perrillo; Ira M Jacobson
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Seminars in liver disease     Volume:  27 Suppl 1     ISSN:  0272-8087     ISO Abbreviation:  Semin. Liver Dis.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110297     Medline TA:  Semin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
Hepatology Division, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA.
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MeSH Terms
Alanine Transaminase / blood*
Antiviral Agents / therapeutic use*
Carcinoma, Hepatocellular / prevention & control,  virology
DNA, Viral / blood*
Hepatitis B virus*
Hepatitis B, Chronic / complications,  drug therapy*,  metabolism*
Liver Cirrhosis / prevention & control,  virology
Liver Neoplasms / prevention & control,  virology
Middle Aged
Practice Guidelines as Topic
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; EC Transaminase

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