| Halting the natural history of hepatitis B viral infection: a paradigm shift. | |
| | |
MedLine Citation:
|
PMID: 17701844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The 2007 American Association for the Study of Liver Diseases (AASLD) practice guidelines for managing chronic hepatitis B virus (HBV) infection recommend pharmacologic therapy for patients with alanine aminotransferase (ALT) activity higher than 2 times the upper limit of normal and serum HBV DNA concentration higher than 20,000 IU/mL. Findings reported over the past several years, however, indicate that HBV infection associated with ALT activity and serum HBV DNA concentrations below these treatment thresholds can progress to serious liver disease, such as cirrhosis or hepatocellular carcinoma. These findings suggest that these treatment thresholds may be too conservative. Moreover, emerging data suggest that, in some patient populations, the appropriate goal of therapy may be sustained suppression of HBV DNA with maintenance antiviral therapy. A satellite symposium conducted during the 57th Annual Meeting of the AASLD in Boston, Massachusetts, presented new findings relative to the course of HBV infection. |
| | |
Authors:
|
Robert P Perrillo; Ira M Jacobson |
Related Documents
:
|
17373754 - A prophylactic approach for bone marrow transplantation from a hepatitis b surface anti... 18410604 - Current treatment of hiv/hepatitis b virus coinfection. 18761934 - A cluster of hepatitis b infections associated with incorrect use of a capillary blood ... 15968334 - Advances in molecular diagnosis of hbv infection and drug resistance. 15584984 - The hepatitis c virus genotype and subtype frequency in hepatitis c virus rna-positive,... 6445224 - Hepatic involvement in the cutaneous t-cell lymphomas: results of percutaneous biopsy a... |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: Seminars in liver disease Volume: 27 Suppl 1 ISSN: 0272-8087 ISO Abbreviation: Semin. Liver Dis. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-08-16 Completed Date: 2007-10-25 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8110297 Medline TA: Semin Liver Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 3-8 Citation Subset: IM |
Affiliation:
|
Hepatology Division, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
blood* Antiviral Agents / therapeutic use* Carcinoma, Hepatocellular / prevention & control, virology DNA, Viral / blood* Hepatitis B virus* Hepatitis B, Chronic / complications, drug therapy*, metabolism* Humans Liver Cirrhosis / prevention & control, virology Liver Neoplasms / prevention & control, virology Male Middle Aged Practice Guidelines as Topic |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/DNA, Viral; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postgraduate training for general practitioners in the Netherlands--a model for Germany? Description...
Next Document: Customizing the management of chronic hepatitis B virus infection.