| Halting metastasis through CXCR4 inhibition. | |
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MedLine Citation:
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PMID: 23211868 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates. |
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Authors:
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Deborah M Ramsey; Shelli R McAlpine |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry, University of New South Wales, Sydney NSW 2052, Australia. Electronic address: d.ramsey@unsw.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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