Document Detail


Haloperidol impairs auditory filial imprinting and modulates monoaminergic neurotransmission in an imprinting-relevant forebrain area of the domestic chick.
MedLine Citation:
PMID:  14535951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In vivo microdialysis and behavioural studies in the domestic chick have shown that glutamatergic as well as monoaminergic neurotransmission in the medio-rostral neostriatum/hyperstriatum ventrale (MNH) is altered after auditory filial imprinting. In the present study, using pharmaco-behavioural and in vivo microdialysis approaches, the role of dopaminergic neurotransmission in this juvenile learning event was further evaluated. The results revealed that: (i) the systemic application of the potent dopamine receptor antagonist haloperidol (7.5 mg/kg) strongly impairs auditory filial imprinting; (ii) systemic haloperidol induces a tetrodotoxin-sensitive increase of extracellular levels of the dopamine metabolite, homovanillic acid, in the MNH, whereas the levels of glutamate, taurine and the serotonin metabolite, 5-hydroxyindole-3-acetic acid, remain unchanged; (iii) haloperidol (0.01, 0.1, 1 mm) infused locally into the MNH increases glutamate, taurine and 5- hydroxyindole-3-acetic acid levels in a dose-dependent manner, whereas homovanillic acid levels remain unchanged; (iv) systemic haloperidol infusion reinforces the N-methyl-d-aspartate receptor-mediated inhibitory modulation of the dopaminergic neurotransmission within the MNH. These results indicate that the modulation of dopaminergic function and its interaction with other neurotransmitter systems in a higher associative forebrain region of the juvenile avian brain displays similar neurochemical characteristics as the adult mammalian prefrontal cortex. Furthermore, we were able to show that the pharmacological manipulation of monoaminergic regulatory mechanisms interferes with learning and memory formation, events which in a similar fashion might occur in young or adult mammals.
Authors:
M Gruss; J Bock; K Braun
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  87     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-10     Completed Date:  2003-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  686-96     Citation Subset:  IM    
Affiliation:
Otto von Guericke University Magdeburg, Institute of Biology, Department of Zoology/Developmental Neurobiology, Germany. gruss@ifn-magdeburg.de
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods
Amino Acids / analysis,  metabolism
Animals
Auditory Perception / physiology
Behavior, Animal / drug effects,  physiology
Biogenic Monoamines / analysis,  metabolism
Chickens / physiology*
Discrimination (Psychology) / drug effects
Extracellular Fluid / chemistry,  metabolism
Female
Glutamic Acid / analysis,  metabolism
Haloperidol / pharmacology*
Homovanillic Acid / analysis,  metabolism
Hydroxyindoleacetic Acid / analysis,  metabolism
Imprinting (Psychology) / drug effects*,  physiology
Male
Microdialysis
N-Methylaspartate / pharmacology
Prosencephalon / drug effects*,  physiology
Synaptic Transmission / drug effects*,  physiology
Taurine / analysis,  metabolism
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 107-35-7/Taurine; 306-08-1/Homovanillic Acid; 52-86-8/Haloperidol; 54-16-0/Hydroxyindoleacetic Acid; 56-86-0/Glutamic Acid; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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