Document Detail

Haloperidol, dynamics of choice, and the parameters of the matching law.
MedLine Citation:
PMID:  17398038     Owner:  NLM     Status:  MEDLINE    
The idea that dopamine mediates the reinforcing effects of stimuli persists in the field of neurosciences. The present study shows that haloperidol, a dopamine antagonist, does not eliminate the reinforcing value of food reinforcers. The ratio of reinforcers changed seven times across two levers within sessions, modeling a dynamic environment. The magnitude of the reinforcer was manipulated independently of the reinforcer ratio. Four doses of intraperitoneal haloperidol were assessed over periods of 12 daily sessions. Haloperidol did not impair the discrimination that the rats established between rich and lean levers; the response distributions favored the lever associated with the higher probability of reinforcement and the larger pellets. The parameters of the generalized matching law (bias and sensitivity) were used to estimate effects of haloperidol upon the motor system and upon the rats' motivation for food reinforcers.
Carlos F Aparicio
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Publication Detail:
Type:  Journal Article     Date:  2007-03-03
Journal Detail:
Title:  Behavioural processes     Volume:  75     ISSN:  0376-6357     ISO Abbreviation:  Behav. Processes     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  206-12     Citation Subset:  IM    
University of Guadalajara-CUCS, Department of Neuroscience, Sierra Mojada 950, Peatonal 3, Edificio N, Guadalajara, Jalisco, México 44340, Mexico.
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MeSH Terms
Choice Behavior / drug effects*
Discrimination Learning / drug effects*
Dopamine Antagonists / pharmacology*
Haloperidol / pharmacology*
Models, Psychological
Random Allocation
Rats, Wistar
Reinforcement (Psychology)*
Reg. No./Substance:
0/Dopamine Antagonists; 52-86-8/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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