Document Detail

Haloperidol decanoate as a replacement for maintenance therapy with intramuscular fluphenazine decanoate in schizophrenia and other chronic psychoses.
MedLine Citation:
PMID:  7180558     Owner:  NLM     Status:  MEDLINE    
Thirty-five psychotic male inpatients receiving optimal neuroleptic maintenance therapy, with fluphenazine decanoate (once every 3-weeks), and one receiving chlorpromazine entered a 24-week study with haloperidol decanoate administered once every 4 weeks, at a dose based on mg equivalence between fluphenazine decanoate and haloperidol decanoate; as regards the latter, this dose was estimated to be comparable with 20 times a daily haloperidol dose. Psychotic symptom severity, evaluated at the end of each treatment period by 8 out of 9 assessed symptoms from the Brief Psychiatric Rating Scale, showed haloperidol decanoate to be of similar efficacy to previously used maintenance medication. The symptom emotional withdrawal was significantly improved by the end of the study. In addition, 18 patients out of 20 were successfully withdrawn from antiparkinsonian therapy without experiencing an enhancement of extrapyramidal side-effects.
K Roose
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta psychiatrica Belgica     Volume:  82     ISSN:  0300-8967     ISO Abbreviation:  Acta Psychiatr Belg     Publication Date:    1982 Mar-Apr
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247037     Medline TA:  Acta Psychiatr Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  216-23     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Delayed-Action Preparations
Dyskinesia, Drug-Induced / etiology
Fluphenazine / adverse effects,  analogs & derivatives*,  therapeutic use
Haloperidol / adverse effects,  analogs & derivatives*,  therapeutic use
Injections, Intramuscular
Middle Aged
Psychotic Disorders / drug therapy*,  psychology
Schizophrenia / drug therapy*
Schizophrenic Psychology
Reg. No./Substance:
0/Delayed-Action Preparations; 5002-47-1/fluphenazine depot; 52-86-8/Haloperidol; 69-23-8/Fluphenazine; 74050-97-8/haloperidol decanoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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