Document Detail

Halofuginone inhibits collagen deposition in fibrous capsules around implants.
MedLine Citation:
PMID:  15725837     Owner:  NLM     Status:  MEDLINE    
Fibrous capsule formation around implants remains a difficult problem that has been studied for decades. The etiology is elusive, but the end result is the deposition of a dense collagenous capsule around implanted materials. The purpose of this study was to determine the effects of a type I collagen synthesis inhibitor, halofuginone, on fibrous capsule formation around implanted materials. Silastic disks were implanted subcutaneously into 4 groups of adult male rats for up to 8 weeks. Group 1 received drug throughout the study, group 2 received drug during the first half only, group 3 received drug during the second half only, and the control group received no drug. Implants were removed and histology of the capsules was examined. A collagen index score was calculated from digital images of trichrome-stained histologic sections, which permitted semiquantitative comparison of collagen content among the 4 groups. The collagen index values clearly indicate that halofuginone effectively inhibited collagen deposition within the capsule around the implanted disks. Halofuginone treatment also resulted in a decrease in the collagen index score in rat skin, indicating that halofuginone may affect preexisting collagenous structures. The ability of halofuginone to inhibit collagen deposition in new and preexisting fibrous capsules suggests that it may be a useful adjunct to minimize the formation of capsules around implantable prostheses.
Kevin C Olbrich; Ricardo Meade; William Bruno; Lior Heller; Bruce Klitzman; L Scott Levin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  54     ISSN:  0148-7043     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-23     Completed Date:  2005-06-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-6;discussion 296     Citation Subset:  IM    
Division of Plastic, Reconstructive, Maxillofacial, and Oral Surgery, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Collagen Type I / antagonists & inhibitors*,  metabolism*
Fibrosis / etiology,  metabolism,  prevention & control
Muscles / metabolism,  pathology
Prostheses and Implants* / adverse effects
Protein Synthesis Inhibitors / pharmacology*
Quinazolines / pharmacology*
Rats, Sprague-Dawley
Silicone Elastomers* / adverse effects
Subcutaneous Tissue / metabolism,  pathology*
Transforming Growth Factor beta / metabolism
Grant Support
Reg. No./Substance:
0/Collagen Type I; 0/Piperidines; 0/Protein Synthesis Inhibitors; 0/Quinazolines; 0/Quinazolinones; 0/Silicone Elastomers; 0/Transforming Growth Factor beta; 17395-31-2/halofuginone

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