Document Detail


Halocycloalkenones as Diels-Alder dienophiles. Applications to generating useful structural patterns.
MedLine Citation:
PMID:  23151095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Halocycloalkenones are demonstrated to function as potent dienophiles in inter- and intramolecular Diels-Alder cycloadditions. We have found 2-brominated cycloalkenone dienophiles to be both highly endo selective and significantly more reactive than their nonhalogenated parent compounds. A method for the facile conversion of brominated cyclobutanone DA adducts to synthetically useful cyclopropyl functional handles is described.
Authors:
Audrey G Ross; Steven D Townsend; Samuel J Danishefsky
Related Documents :
25204895 - Palladium-catalyzed annulation of diarylamines with olefins through ch activation: d...
17638705 - Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin res...
24589915 - The carbomethylation of arylacrylamides leading to 3-ethyl-3-substituted indolin-2-one ...
24166035 - Synthesis of nitric oxide probes with fluorescence lifetime sensitivity.
20645655 - Understanding the molecular behavior of organotin compounds to design their effective u...
21680155 - 1-(2,4-dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylpheny)propane inhibits melanin synthes...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-27
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  78     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-07     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  204-10     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cyclization
Cycloparaffins / chemistry*
Hydrocarbons, Halogenated / chemistry*
Stereoisomerism
Grant Support
ID/Acronym/Agency:
CA062948/CA/NCI NIH HHS; HL25848/HL/NHLBI NIH HHS; R01 HL025848/HL/NHLBI NIH HHS; T32 CA062948/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Cycloparaffins; 0/Hydrocarbons, Halogenated
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anti-inflammatory action of Tamarind seeds reduces hyperglycemic excursion by repressing pancreatic ...
Next Document:  Atomic Mobility in a Polymer Glass after Shear and Thermal Cycles.