Document Detail

Halo nevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo.
MedLine Citation:
PMID:  22032627     Owner:  NLM     Status:  Publisher    
Background:  Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and non-segmental vitiligo, has been rarely reported. Objective:  The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo. Patients and Methods:  This was a prospective observational study conducted in the vitiligo clinic of the department of dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was informed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after exclusion of other forms of vitiligo (focal, mucosal, not classifiable.) Thyroid function and anti-thyroid antibodies were screened if not obtained in the previous year. Results:  127 patients were recruited. 101 had segmental vitiligo and 26 had segmental vitiligo that evolved into mixed vitiligo. 56 were males and 71 were females. Most patients had an onset of segmental vitiligo before the age of 18. When conducting multivariate analysis, we found initial percentage of body surface involvement of the segment of more than 1% (OR: 15.14, p=0.003), the presence of halo nevi (OR: 24.82, p=0.0001) and leukotrichia (OR: 25.73, p=0.0009) were found to be independent factors associated with the evolution of patients from segmental vitiligo to mixed vitiligo Conclusion:  Halo nevi association and leukotrichia at first consultation in segmental vitiligo are risk factors for progression of segmental vitiligo to mixed vitiligo. In addition, this progression of SV to MV carries a stronger link if initial segmental involvement is situated on the trunk.
K Ezzedine; A Diallo; C Léauté-Labrèze; J Séneschal; S Prey; F Ballanger; K Alghamdi; M Cario-André; T Jouary; Y Gauthier; A Taieb
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-27
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Department of Dermatology and Pediatric Dermatology; National Centre for Rare Skin Disorders, Hôpital Pellegrin, Bordeaux, France University of Bordeaux and Inserm U1035, University of Bordeaux, Bordeaux, France. Department of Dermatology, Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
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