Document Detail

Hallucinatory disorder, an original clinical picture? Clinical and imaging data.
MedLine Citation:
PMID:  18037549     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to verify the existence of areas of clinical and neurofunctional homogeneity in a group of patients with auditory verbal hallucinations (AVHs) as an isolated symptom, attributable to what we have called "Hallucinatory Disorder" (HD) in an attempt to propose a clinical picture that is distinct from Schizophrenia. METHOD: Nine patients clinically characterised by chronic AVHs were compared with nine schizophrenic patients using the Structured Clinical Interview for DSM-III-R, BPRS, PANSS, SAPS, SANS, HRS-A, HRS-D, CDSS, MMSE, CGI and PSYRATS. Both groups of patients and nine healthy subjects underwent EEG and SPECT examinations. RESULTS: Considering the psychopathological dimensions of Schizophrenia, in the HD patients clinical evaluations revealed a mono-dimensional clinical profile, whereas all these dimensions contributed to the clinical picture of the schizophrenic patients. The SPECT data showed that the schizophrenic patients had a reduced rCBF in some areas of the right frontal lobe, while the HD patients did not show any area of hypoperfusion. The SPECT hyperperfusion data showed an activation pattern in the HD patients that was characterised by the involvement of various cortical and subcortical cerebral areas, similar to those found in studies of inner speech and auditory verbal imagery. CONCLUSIONS: The two groups of patients present significant differences that seem capable of supporting the proposed hypothesis that HD may be an independent nosographical entity.
Massimo C Mauri; Marco Gaietta; Filippo Dragogna; Isabel Valli; Giancarlo Cerveri; Giorgio Marotta
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-10-25
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  32     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  523-30     Citation Subset:  IM    
Clinical Psychiatry, Clinical Neuropsycopharmacology Unit, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
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MeSH Terms
Brain / blood supply,  radionuclide imaging
Chronic Disease
Diagnosis, Differential
Frontal Lobe / blood supply,  radionuclide imaging
Functional Laterality / physiology
Hallucinations / classification,  diagnosis*,  radionuclide imaging
Psychiatric Status Rating Scales / statistics & numerical data
Schizophrenia / classification,  diagnosis*,  radionuclide imaging
Schizophrenic Psychology*
Terminology as Topic
Tomography, Emission-Computed, Single-Photon

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