Document Detail

Halitosis associated volatiles in breath of healthy subjects.
MedLine Citation:
PMID:  17416556     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Halitosis can have an intra- or extra-oral origin. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. They can be specific for certain diseases or infections. STUDY OBJECTIVE: This study explored the presence and concentration of these volatile compounds normally associated with halitosis in the breath of healthy symptomless volunteers. METHODS: Alveolar and mouth air of 40 healthy volunteers as well as environmental air were analyzed by gas chromatography-mass spectrometry (GC-MS) and by a commercially available GC device (OralChroma). RESULTS: 14 compounds, associated with halitosis could be detected. All of them except carbon disulfide, appeared to be (partly) produced endogenously and/or in the mouth. Acetone, 2-butanone, 2-pentanone and 1-propanol were common to all volunteers in both alveolar and mouth air and indole and dimethyl selenide in alveolar air. CONCLUSIONS: GC-MS seems a promising tool for differential diagnosis of halitosis, with the possibility to detect extra-oral causes, which often remain undetected unless characterized by a specific smell.
Sandra van den Velde; Marc Quirynen; Paul van Hee; Daniel van Steenberghe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-14
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  853     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-30     Revised Date:  2008-04-01    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  54-61     Citation Subset:  IM    
Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium.
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MeSH Terms
1-Propanol / analysis,  chemistry
Acetone / analysis,  chemistry
Breath Tests / methods
Butanones / analysis,  chemistry
Gas Chromatography-Mass Spectrometry / methods
Halitosis / metabolism*,  pathology
Organic Chemicals / analysis*,  chemistry
Pentanones / analysis,  chemistry
Reproducibility of Results
Sulfur Compounds / analysis,  chemistry
Reg. No./Substance:
0/Butanones; 0/Organic Chemicals; 0/Pentanones; 0/Sulfur Compounds; 107-87-9/2-pentanone; 67-64-1/Acetone; 71-23-8/1-Propanol; 78-93-3/methylethyl ketone
Comment In:
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):263; author reply 264   [PMID:  17804305 ]

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