Document Detail


Halicloic Acids A and B Isolated from the Marine Sponge Haliclona sp. Collected in the Philippines Inhibit Indoleamine 2,3-Dioxygenase.
MedLine Citation:
PMID:  22873824     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Two new merohexaprenoids, halicloic acids A (1) and B (2), have been isolated from the marine sponge Haliclona (Halichoclona) sp. collected in the Philippines. The glycolic acids 1 and 2 slowly decomposed during acquisition of NMR data to aldehydes 3 and 4, respectively, via an oxidative decarboxylation. Halicloic acid B (2) has the new rearranged "haliclane" meroterpenoid carbon skeleton. The halicloic acids 1 and 2 are indoleamine 2,3-dioxygenase inhibitors that are significantly more active than the decomposition products 3 and 4.
Authors:
David E Williams; Anne Steinø; Nicole J de Voogd; A Grant Mauk; Raymond J Andersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia , Vancouver, B.C., Canada, V6T 1Z1.
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