| Half-dose aprotinin does not affect haemorheological properties in patients undergoing bypass surgery. | |
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MedLine Citation:
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PMID: 8922889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate haemorheological changes in patients undergoing coronary artery bypass grafting and to determine whether the protective effect on haemorheology of high-dose aprotinin also exists under a half-dose regimen. METHODS: Forty patients were studied in a double-blind, placebo-controlled study design. Patients in the aprotinin group received half of the standard high dose of aprotinin during surgery. Erythrocyte and white-cell clogging rates as well as whole blood and plasma viscosity were measured. Viscosity results were expressed as a ratio to the viscosity of saline. RESULTS: Erythrocyte and white-cell clogging rates were increased significantly, whereas whole blood and plasma viscosity were decreased significantly during cardiopulmonary bypass. The reduction in viscosity had a strong correlation to haemodilution. There was no significant difference in any of the measured variables between the aprotinin and the placebo groups. CONCLUSION: This study showed that blood cell damage occurred during cardiopulmonary bypass surgery, as measured by a raised clogging rate. This tendency was the same in both groups and therefore no increased potential for microthrombi could be attributed to aprotinin haemorheologically. However, half-dose aprotinin did not show any preserving effect in haemorheology when the blood-cell clogging rate and blood viscosity were studied. |
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Authors:
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B Liu; A Belboul; G Rådberg; L Dernevik; Z Liang; E Berglin; D Roberts |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Coronary artery disease Volume: 7 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-02-26 Completed Date: 1997-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 609-13 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Sahlgrenska Hospital, University of Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aprotinin / administration & dosage, therapeutic use* Blood Coagulation / drug effects* Blood Viscosity / drug effects* Coronary Artery Bypass* Dose-Response Relationship, Drug Double-Blind Method Female Hemostatics / administration & dosage, therapeutic use* Humans Male Middle Aged Reference Values Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Hemostatics; 9087-70-1/Aprotinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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