Document Detail

Hairpin- and cruciform-mediated chromosome breakage: causes and consequences in eukaryotic cells.
MedLine Citation:
PMID:  17485368     Owner:  NLM     Status:  MEDLINE    
Chromosomes of many eukaryotic organisms including humans contain a large number of repetitive sequences. Several types of commonly present DNA repeats have the capacity to adopt hairpin and cruciform secondary structures. Inverted repeats, AT- and GC-rich micro- and minisatellites, comprising this class of sequence motifs, are frequently found in chromosomal regions that are prone for gross rearrangements in somatic and germ cells. Recent studies in yeast and mammals indicate that a double-strand break occurring at the sites of unstable repeats can be an initial event in the generation of chromosome rearrangements. The repeat-induced chromosomal instability is responsible for a number of human diseases and has been implicated in carcinogenesis. In this review, we discuss the molecular mechanisms by which hairpins and cruciforms can trigger chromosomal fragility and subsequent aberrations in eukaryotic cells. We also address the relationship between secondary structure-mediated genetic instability and human pathology.
Kirill S Lobachev; Alison Rattray; Vidhya Narayanan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2007-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  12     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4208-20     Citation Subset:  IM    
School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
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MeSH Terms
Chromosome Aberrations*
Genomic Instability
Nucleic Acid Conformation*

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