Document Detail


Hair mercury levels, fish consumption, and cognitive development in preschool children from Granada, Spain .
MedLine Citation:
PMID:  19909946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The main source of human exposure to mercury is the consumption of fish contaminated with methylmercury, which may adversely affect early neurodevelopment. This study assessed mercury levels in hair of preschoolers in Spain, where fish consumption is elevated, with the aim of investigating the influence of their fish intake and other factors on mercury exposure, and evaluating their association with cognitive development. A population-based birth cohort from Granada (Spain) was studied at the age of 4yr. Total mercury (T-Hg) levels were determined in children's hair, and daily fish intake was assessed by a food frequency questionnaire. The McCarthy Scales of Children's Abilities (MSCA) were used to assess children's motor and cognitive abilities. Complete data were gathered on 72 children, and multivariate analyses were performed to evaluate the influence of mercury exposure and fish intake on MSCA outcomes. Mean concentration of T-Hg in hair was 0.96 microg/g (95% confidence interval=0.76; 1.20 microg/g). T-Hg levels were associated with higher frequency of oily fish consumption, place of residence, maternal age, and passive smoking. After adjustment for fish intake, T-Hg levels > or =1microg/g were associated with decrements in the general cognitive (-6.6 points), memory (-8.4 points), and verbal (-7.5 points) MSCA scores. Higher mercury exposure in children from this Mediterranean area was associated with cognitive development delay. Studies on the putative benefits of fish intake during early development should consider mercury exposure from different fish species.
Authors:
Carmen Freire; Rosa Ramos; Maria-Jose Lopez-Espinosa; Sergi Díez; Jesús Vioque; Ferrán Ballester; Mariana-Fátima Fernández
Related Documents :
3696196 - Total mercury and its distribution in blue crab and deep water pink shrimp from alexand...
17030106 - Further evidence of in vitro production of gamma-hydroxybutyrate (ghb) in urine samples.
16570636 - Impairment of cellular immunity in west greenland sledge dogs (canis familiaris) dietar...
1510586 - Blood mercury and serum selenium concentrations in reindeer herders in the arctic area ...
19411026 - A retrospective study of enteroclysis in patients with manifest food allergy.
6308996 - The hypolipidemic effect of locust bean gum food products in familial hypercholesterole...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental research     Volume:  110     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-104     Citation Subset:  IM    
Affiliation:
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), 18071 Granada, Spain. cfreire@ugr.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Child Development / drug effects*
Child, Preschool
Cities
Cognition / drug effects*
Cohort Studies
Cross-Sectional Studies
Eating*
Environmental Monitoring
Fishes*
Hair / chemistry*
Humans
Mercury / analysis,  pharmacokinetics,  toxicity*
Methylmercury Compounds / analysis,  pharmacokinetics,  toxicity
Multivariate Analysis
Rural Population / statistics & numerical data
Spain
Urban Population / statistics & numerical data
Water Pollutants, Chemical / analysis,  pharmacokinetics,  toxicity*
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 0/Water Pollutants, Chemical; 7439-97-6/Mercury

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  When hearing the bark helps to identify the dog: Semantically-congruent sounds modulate the identifi...
Next Document:  A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expre...