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Hair dye ingestion--an uncommon cause of acute kidney injury.
MedLine Citation:
PMID:  20329439     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: Dye containing paraphenylene diamine is not an uncommon cause of renal failure in South India. However, there are very few published reports on renal lesions associated with hair dye ingestion.
MATERIAL AND METHODS: We studied 30 consecutive cases (24 males and 6 females) of hair dye induced renal failure seen at our department. All the patients were aged between 18 to 40 years (26.9 +/- 4.95 years).
RESULTS: The quantity of dye consumed ranged between 50-100 ml (79.5 +/- 22.45). All patients presented with oliguria and fluid overload. Dyspnea was seen in 24 (80%) while 10 (33.33%) had hypertension. Encephalopathy and seizures were seen in 10 (33.3%). None of the patients had evidence of hemolysis, hematological abnormalities or skin rash. Three patients had elevated SGPT (340 IU/l) which returned to base line after 2 weeks while creatinine phosphokinase (CPK) was elevated in 6(20%) patients. The oliguric phase lasted from 1 to 3 weeks and serum creatinine normalized in 21 (70%) patients. Renal biopsy done in 15 patients (done antemortem in 10 and postmortem in 5) showed evidence of acute tubular necrosis (ATN) in 8, acute interstitial nephritis (AIN) in 7 patients. All patients received dialytic support. Eight (26.6%) patients succumbed.
CONCLUSION: Hair dye is an unusual but important cause of acute kidney injury. The commonest renal lesions are acute tubulointerstitial damage. Respiratory and hemodynamic supportive therapy is essential for recovery.
Authors:
Manisha Sahay; R Vani; Sharmas Vali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  57     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-03-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  743-4     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Osmania Medical College & Osmania Hospital, Afzalgunj, Hyderabad.
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