Document Detail


Hair cortisol as a potential biologic marker of chronic stress in hospitalized neonates.
MedLine Citation:
PMID:  17356304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: As preterm and term infants in the neonatal intensive care unit (NICU) undergo multiple stressful/painful procedures, research is required that addresses chronic stress. OBJECTIVES: To determine whether (a) hair cortisol levels differed between term and preterm infants exposed to stress in the NICU and (b) an association exists between hair cortisol levels and severity of illness or indicators of acute stress. METHODS: Hair cortisol levels were determined using the ELISA method (solid-phase enzyme-linked immunoassay, Alpco Diagnostics, Windham, N.H., USA) in 60 infants >25 weeks gestational age at birth. RESULTS: No significant differences were found between the hair cortisol levels of term infants compared to preterm infants in the NICU. When compared to a group of healthy term infants, hospitalized infants had significantly higher hair cortisol levels (t (76) = 2.755, p = 0.004). A subgroup analysis of the term NICU infants showed a statistically significant association between total number of ventilator days and hair cortisol levels. For every extra day on the ventilator, hair cortisol levels increased on average by 0.2 nmol/g (p = 0.03). 21% of the variance in hair cortisol levels was explained by the total number of days on the ventilator. CONCLUSIONS: Hair cortisol is influenced by days of ventilation in NICU term infants. This is a potentially valid outcome for chronic neonatal stress in these infants and warrants further investigation.
Authors:
Janet Yamada; Bonnie Stevens; Nicole de Silva; Sharyn Gibbins; Joseph Beyene; Anna Taddio; Christine Newman; Gideon Koren
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-14
Journal Detail:
Title:  Neonatology     Volume:  92     ISSN:  1661-7800     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-08-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  42-9     Citation Subset:  IM    
Affiliation:
Faculties of Nursing and Medicine, University of Toronto, Toronto, Ont., Canada. janet.yamada@sickkids.ca
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism
Critical Illness / therapy
Enzyme-Linked Immunosorbent Assay
Female
Hair / metabolism*
Humans
Hydrocortisone / metabolism*
Infant, Newborn / metabolism*
Infant, Premature / metabolism*
Intensive Care Units, Neonatal
Male
Pain / metabolism
Prospective Studies
Respiration, Artificial*
Severity of Illness Index
Stress, Physiological / metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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