Document Detail

Hair cell development: commitment through differentiation.
MedLine Citation:
PMID:  16626654     Owner:  NLM     Status:  MEDLINE    
The perceptions of sound, balance and acceleration are mediated through the vibration of stereociliary bundles located on the lumenal surfaces of mechanosensory hair cells located within the inner ear. In mammals, virtually all hair cells are generated during a relatively brief period in embryogenesis with any subsequent hair cell loss leading to a progressive and permanent loss of sensitivity. In light of the importance of these cells, considerable effort has been focused on understanding the molecular genetic pathways that regulate their development. The results of these studies have begun to elucidate the signaling molecules that regulate several key events in hair cell development. In particular, significant progress has been made in the understanding of hair cell commitment, survival and differentiation. In addition, several aspects of the development of the stereociliary bundle, including its elongation and orientation, have recently been examined. This review will summarize results from each of these developmental events and describe the molecular signaling pathways involved.
Matthew W Kelley
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-13
Journal Detail:
Title:  Brain research     Volume:  1091     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  172-85     Citation Subset:  IM    
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 35 Convent Drive, Bethesda, MA 20892, USA.
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MeSH Terms
Cell Differentiation / physiology*
Cochlea / cytology*,  growth & development
Hair Cells, Auditory / growth & development*
Thyroid Hormones / physiology
Reg. No./Substance:
0/Thyroid Hormones

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