Document Detail


Hair as a novel noninvasive method to study the impact of pregnancy on CYP2D6 metabolizing capacity.
MedLine Citation:
PMID:  19701115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel method is described to investigate changes in the drug metabolizing capacity of CYP2D6 during pregnancy using hair analysis.
Authors:
Lisa O'Brien; Carina Baumer; Detlef Thieme; Hans Sachs; Gideon Koren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  31     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-2     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada. lobrien14@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution
Cytochrome P-450 CYP2D6 / genetics*,  metabolism
Dose-Response Relationship, Drug
Drug Monitoring
Female
Gene Duplication
Genotype
Hair / metabolism*
Hair Color / genetics*
Humans
Male
Metabolic Clearance Rate / genetics
Mutagenesis, Site-Directed
Pharmaceutical Preparations
Phenotype
Pregnancy
Pregnancy Complications*
Substrate Specificity / genetics
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; EC 1.14.14.1/Cytochrome P-450 CYP2D6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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