| Hair Cortisol Content in Patients with Adrenal Insufficiency on Hydrocortisone Replacement Therapy. | |
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MedLine Citation:
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PMID: 21521272 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Patients with adrenal insufficiency (AI) require life-long replacement therapy with exogenous glucocorticoids. Several studies have shown impaired subjective health status in these patients as well as increased morbidity and mortality risk, which may be caused by glucocorticoid over-replacement. Objective: As a measure of long-term cortisol exposure, the usefulness of hair cortisol analysis in patients receiving glucocorticoid replacement therapy was investigated. Patients and design: Hair samples, demographics, medical history and perceived stress scale (PSS) questionnaires were collected from 93 patients across North America diagnosed with primary or secondary AI. Sixty-two household partners served as a control group. Cortisol was measured in the proximal 2 cm of hair, representing the most recent 2 months of exposure. A modified enzyme immunoassay was used for measurement of cortisol. Results: The male patients had significantly higher hair cortisol levels than the male controls (p<0.05), while there was no significant difference among females. Hair cortisol content correlated significantly with glucocorticoid dose (r=0.3, p<0.01). Patients with AI had significantly higher subjective stress scores than control subjects. Conclusions: Hair cortisol content correlates with HC dose in patients with AI. Our results suggest that some AI patients may be over-treated and, hence, may be at risk for the adverse effects of cortisol. Measurement of HC in hair may become a useful monitoring tool for long-term cortisol exposure in patients treated with glucocorticoids. |
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Authors:
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Rachel Gow; Gideon Koren; Michael Rieder; Stan Van Uum |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Dept. of Physiology and Pharmacology Pediatrics and Physiology/Pharmacology CIHR-GSK Chair in Pediatric Clinical Pharmacology, Children's Health Research Institute Dept. of Medicine Ivey Chair in Molecular Toxicology Lawson Health Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario Div. of Clinical Pharmacology/Toxicology, Hospital for Sick Children, Toronto, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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