| Hair Biomarkers as Measures of Maternal Tobacco Smoke Exposure and Predictors of Fetal Growth. | |
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MedLine Citation:
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PMID: 21330286 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Most biomarker studies of the effects of maternal smoking on fetal growth have been based on a single blood or urinary cotinine value, which is inadequate in capturing maternal tobacco exposure over the entire pregnancy. We used hair biomarkers to compare the associations of maternal self-reported smoking, hair nicotine, and hair cotinine with birth weight for gestational age (BW for GA) among active and passive smokers during pregnancy. METHODS: We collected maternal hair in the immediate postpartum period and measured nicotine and cotinine concentrations averaged over the pregnancy in 444 term controls drawn from 5,337 participants in a multicenter nested case-control study of preterm birth. BW for GA Z-score and small for gestational age (SGA) were based on Canadian population-based standards. RESULTS: The addition of hair nicotine to multiple linear regression models containing self-reported active smoking, hair cotinine, or both explained significantly more variance in the BW for GA Z-score (p = .01, .03 and .04, respectively). Similarly, women with hair nicotine, but not cotinine, at or above the median value had a significant increase in the risk of SGA birth (odds ratio: 3.07, 95% CI: 1.25-7.52). No significant association was observed between maternal passive smoking and BW for GA based on hair biomarkers. Conclusions: Hair nicotine is a better predictor of reductions in BW for GA than either hair cotinine or self-report. Our negative results for passive smoking suggest that previously reported small but significant effects may be explained by misclassification of active smokers as passive smokers based on self-report. |
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Authors:
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Nisha D Almeida; Gideon Koren; Robert W Platt; Michael S Kramer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-4 |
Journal Detail:
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Title: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Volume: - ISSN: 1469-994X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815751 Medline TA: Nicotine Tob Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1140 Pine Avenue West, Montreal, Quebec H3A 1A3, Canada. nisha.almeida@mail.mcgill.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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