Document Detail


Hair Biomarkers as Measures of Maternal Tobacco Smoke Exposure and Predictors of Fetal Growth.
MedLine Citation:
PMID:  21330286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Most biomarker studies of the effects of maternal smoking on fetal growth have been based on a single blood or urinary cotinine value, which is inadequate in capturing maternal tobacco exposure over the entire pregnancy. We used hair biomarkers to compare the associations of maternal self-reported smoking, hair nicotine, and hair cotinine with birth weight for gestational age (BW for GA) among active and passive smokers during pregnancy. METHODS: We collected maternal hair in the immediate postpartum period and measured nicotine and cotinine concentrations averaged over the pregnancy in 444 term controls drawn from 5,337 participants in a multicenter nested case-control study of preterm birth. BW for GA Z-score and small for gestational age (SGA) were based on Canadian population-based standards. RESULTS: The addition of hair nicotine to multiple linear regression models containing self-reported active smoking, hair cotinine, or both explained significantly more variance in the BW for GA Z-score (p = .01, .03 and .04, respectively). Similarly, women with hair nicotine, but not cotinine, at or above the median value had a significant increase in the risk of SGA birth (odds ratio: 3.07, 95% CI: 1.25-7.52). No significant association was observed between maternal passive smoking and BW for GA based on hair biomarkers. Conclusions: Hair nicotine is a better predictor of reductions in BW for GA than either hair cotinine or self-report. Our negative results for passive smoking suggest that previously reported small but significant effects may be explained by misclassification of active smokers as passive smokers based on self-report.
Authors:
Nisha D Almeida; Gideon Koren; Robert W Platt; Michael S Kramer
Related Documents :
21376476 - Hla-g and pregnancy adverse outcomes.
24235946 - Association of anti-chlamydia antibodies with ectopic pregnancy in benin city, nigeria:...
8773426 - Purified neem (azadirachta indica) seed extracts (praneem) abrogate pregnancy in primates.
21231846 - Comparison of c-reactive protein levels in pregnancies with retained and removed intrau...
8096796 - Genetic analysis of repeated, biparental, diploid, hydatidiform moles.
18816476 - Cervical length and maternal factors in expectantly managed prolonged pregnancy: predic...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-4
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  -     ISSN:  1469-994X     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1140 Pine Avenue West, Montreal, Quebec H3A 1A3, Canada. nisha.almeida@mail.mcgill.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An Internet-Based Smoking Cessation Program for Korean Americans: Results From a Randomized Controll...
Next Document:  Flower: extracting information from pyrosequencing data.