Document Detail

Hageman factor and risk of myocardial infarction in middle-aged men.
MedLine Citation:
PMID:  1445495     Owner:  NLM     Status:  MEDLINE    
In order to evaluate whether Hageman factor (XII) is increased in survivors of myocardial infarction and whether this in turn influences factor VII coagulant activity (VIIc), we examined the coagulation and lipoprotein profiles in 82 subjects, 51 of whom had a definite history of myocardial infarction and 31 healthy volunteers invited from a local general practice register for a cardiovascular screen. Both serum cholesterol (P = 0.03) and plasma fibrinogen levels (P = 0.02) were significantly elevated in cases compared with controls. There were no significant differences in coagulant activities, and in particular factor XII concentration was not significantly different between groups. Furthermore, in 47 of the subjects, 28 of whom had a history of myocardial infarction, a more detailed analysis, including measurement of VIIc after overnight incubation of plasma at 4 degrees C, was undertaken. Approximately half the subjects in either group showed some evidence of activation, though history of myocardial infarction was not in itself a significant predictor of this. All measures of XII concentration related positively to VIIc after cold activation, the strongest being the measure of amidolytic activity following activation of factor XII (XIIAm) (r = 0.5, P < 0.01). In addition, XIIa, a measure of activity due to enzymes derived from factor XII, related strongly to many of the measured lipoprotein variables, particularly VLDL cholesterol and triglycerides, supporting the hypothesis that negatively charged molecules such as free fatty acids on larger lipoprotein particles provide the contact surface necessary to activate factor XII. The findings confirm the importance of this alternative pathway in leading to activation of factor VII.
C C Kelleher; K A Mitropoulos; J Imeson; T W Meade; J C Martin; B E Reeves; L O Hughes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  97     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-14     Completed Date:  1992-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
MRC Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, Medical College of St. Bartholomew's Hospital, London, UK.
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MeSH Terms
Antigens / analysis
Cholesterol / blood
Factor VII / analysis
Factor XII / analysis*
Fibrinogen / analysis
Lipoproteins / blood
Middle Aged
Myocardial Infarction / blood*
Risk Factors
Reg. No./Substance:
0/Antigens; 0/Lipoproteins; 0/factor VII clotting antigen; 57-88-5/Cholesterol; 9001-25-6/Factor VII; 9001-30-3/Factor XII; 9001-32-5/Fibrinogen

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