Document Detail

Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
MedLine Citation:
PMID:  19732942     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The haemostatic and biochemical abnormalities participate in the progression of cardiovascular disease (CVD) in peritoneally dialysed (PD) patients. Recently, the role of kynurenine (KYN) pathway of tryptophan (TRP) degradation in the development of CVD has been postulated. MATERIALS AND METHODS: The present study was undertaken to investigate haemostatic parameters, biochemical profiles and kynurenines in PD patients both with and without CVD compared to age- and sex-matched healthy controls. RESULTS: The multiple biochemical abnormalities were present in PD patients, particularly in those with CVD. Tissue factor (TF), its inhibitor (TFPI), prothrombin fragment 1+2 (F(1+2)), urokinase-type plasminogen activator (uPA), its soluble receptor (suPAR), plasmin/antiplasmin (PAP) complexes, KYN, kynurenic (KYNA) and quinolinic (QA) acids levels were significantly higher, whereas TRP was significantly lower in the PD patients than in the controls. Tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) were higher in the patients with CVD than in the patients without CVD and controls. PD patients with CVD had higher F(1+2), and they had lower suPAR and KYNA levels compared with PD patients without CVD. KYNA was positively associated with TFPI, whereas its was inversely associated with F(1+2) both in the whole PD group and in CVD patients. Logistic regression analysis showed that low KYNA, high glucose, low HDL-cholesterol levels and the duration of dialysis treatment were independently associated with the presence of CVD in PD patients. CONCLUSIONS: The present study suggests a relationship between kynurenine pathway of tryptophan degradation, haemostatic and biochemical disturbances and CVD prevalence in peritoneally dialyzed patients.
Krystyna Pawlak; Michal Mysliwiec; Dariusz Pawlak
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-03
Journal Detail:
Title:  Thrombosis research     Volume:  125     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e40-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland.
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MeSH Terms
Antifibrinolytic Agents / metabolism
Cardiovascular Diseases / epidemiology*
Case-Control Studies
Cross-Sectional Studies
Fibrinolysin / metabolism
Kynurenic Acid / metabolism
Kynurenine / metabolism*
Middle Aged
Peptide Fragments / metabolism
Peritoneal Dialysis, Continuous Ambulatory / methods
Plasminogen Activator Inhibitor 1 / metabolism
Poland / epidemiology
Prothrombin / metabolism
Quinolinic Acid / metabolism
Receptors, Urokinase Plasminogen Activator
Thromboplastin / metabolism
Tryptophan / metabolism
Urokinase-Type Plasminogen Activator / metabolism
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Peptide Fragments; 0/Plasminogen Activator Inhibitor 1; 0/Receptors, Urokinase Plasminogen Activator; 0/prothrombin fragment 1.2; 343-65-7/Kynurenine; 492-27-3/Kynurenic Acid; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid; 9001-26-7/Prothrombin; 9035-58-9/Thromboplastin; EC; EC Plasminogen Activator

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