Document Detail

Haemostatic profile of healthy premature small for gestational age neonates.
MedLine Citation:
PMID:  20542543     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The pathogenetic profile of premature Small for Gestational Age (SGA) neonates is strongly related to their haemostatic equilibrium, which is inadequately understood.
OBJECTIVE: To evaluate coagulation and fibrinolysis in premature SGA neonates before intervening with Vitamin K administration.
STUDY DESIGN: We performed a comparison of coagulation, natural inhibitors and fibrinolysis between SGA and Appropriate for Gestational Age (AGA) infants born prematurely [gestational age (G.A.) <37 weeks]. Study population consisted of 139 preterm newborns, 68 of whom were SGA (25 males and 43 females), while 71 were AGA (37 males and 34 females) that consisted the control group. Blood samples were obtained within 30 minutes following birth and before the administration of vitamin K. Investigation included: PT, INR, APTT, fibrinogen, coagulation factors II, V, VII, VIII, IX, X, XI, XII, von Willebrand factor, protein C and free protein S, antithrombin (AT), APCR, tPA and PAI-1. The independent t-test and the Mann-Whitney U test were used to compare the differences between the values of haemostatic parameters.
RESULTS: Premature SGA infants presented significantly lower levels of fibrinogen (p<0.029) and higher levels of VIIIc factor, APCR, tPA and PAI-1 (p<0.041, 0.017, 0.021 and 0.019 respectively). The two groups had similar demographic characteristics (except from birth weight), without significant differences in the values of other haemostatic parameters.
CONCLUSIONS: Despite the statistically significant differentiation in the levels of fibrinogen, VIIIc factor, APCR, tPA and PAI-1, the rest of haemostatic parameters have similar values between SGA and AGA preterms.
George Mitsiakos; Evaggelia Giougi; Ilias Chatziioannidis; Paraskevi Karagianni; Emmanouil Papadakis; Christos Tsakalidis; Georgia Papaioannou; Pavlos Malindretos; Nikolaos Nikolaidis
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Thrombosis research     Volume:  126     ISSN:  1879-2472     ISO Abbreviation:  Thromb. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-6     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Ltd. All rights reserved.
2nd NICU and Nueonatology Department of Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Ring Road Nea Efkarpia, T.K. 56403 Thessaloniki, Greece.
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MeSH Terms
Blood Coagulation Tests
Infant, Newborn
Infant, Premature*
Infant, Small for Gestational Age*

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