Document Detail

Haemostatic disorders and respiratory distress in the newborn.
MedLine Citation:
PMID:  73554     Owner:  NLM     Status:  MEDLINE    
Coagulation and fibrinolysis studies were performed on 64 newborns; 16 premature infants with hyaline membrane disease (HMD), 17 newborns with other forms of respiratory distress syndrome (RDS) (8 of them were premature), 31 healthy newborns (11 of them were premature). All the babies were studied once in the first 48 hours of life. There was no significant difference between sick and healthy babies for 5 parameters; platelet count, factor VIII, fibrinogen, fibrin(ogen) degradation products, euglobulin lysis time. Factor II, VII and X were low in all infants, and premature infants had significantly lower levels compared to full term newborns. Factor V, plasminogen, alpha 2 macroglobulin (alpha 2M) and antithrombin III (AT III) levels were significantly lower in sick infants. Except for AT III, these deficiencies were not related to prematurity. No significant difference was found between HMD and other RDS. Of the 33 sick infants, 5 developed laboratory findings consistent with disseminated intravascular coagulation (DIC). The results indicate that the coagulation and fibrinolytic abnormalities reported are not specific to HMD.
C Boyer; D Ménaché; F Beaufils; H Mathieu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  3     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1977 Dec 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
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MeSH Terms
Antithrombins / blood
Blood Cell Count
Blood Coagulation
Blood Coagulation Factors / analysis
Blood Platelets
Clinical Trials as Topic
Disseminated Intravascular Coagulation / complications
Hyaline Membrane Disease / blood
Infant, Newborn*
Infant, Premature
Respiratory Distress Syndrome, Newborn / blood*,  complications
alpha-Macroglobulins / analysis
Reg. No./Substance:
0/Antithrombins; 0/Blood Coagulation Factors; 0/alpha-Macroglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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