Document Detail

Haemostatic derangement in patients with intracranial tumours.
MedLine Citation:
PMID:  7718166     Owner:  NLM     Status:  MEDLINE    
Forty-five patients with brain tumours were studied for evidence of any haemostatic abnormalities in the preoperative and intraoperative period. An abnormality was found in 44 of the patients in the preoperative period and in all the patients during the operation. One patient developed acute disseminated intravascular coagulation. A change in the haemostatic abnormality from the preoperative to the intraoperative period was demonstrated in 9 of the patients. The histological nature of the tumour did not influence the haemostatic derangement. A shortened euglobulin lysis time, prolonged thrombin time, increased fibrin degradation products and abnormal fibrinogen levels were the common isolated abnormalities. When considered together, chronic disseminated intravascular coagulation (DIC) with or without fibrinolysis and fibrinolysis with or without DIC were the commonest abnormalities. Although some degree of haemostatic derangement is found in a high proportion of patients with brain tumours, clinically relevant abnormalities are rare.
K S Prasad; B S Sharma; N Marwaha; R S Sarode; V K Kak
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of neurosurgery     Volume:  8     ISSN:  0268-8697     ISO Abbreviation:  Br J Neurosurg     Publication Date:  1994  
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800054     Medline TA:  Br J Neurosurg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Blood Coagulation Disorders
Brain / pathology*
Brain Neoplasms / pathology*
Disseminated Intravascular Coagulation*
Hemostasis, Surgical*
Intraoperative Complications
Middle Aged

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