Document Detail


Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage.
MedLine Citation:
PMID:  17393017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied some biophysical properties of the fibrin network during the normal state of pregnancy and in patients with recurrent miscarriage (RM), in the first trimester of pregnancy. The fibrin polymerization process, followed by turbidity, showed that the rate of fibrin monomer assembly and the final turbidity was increased in the pregnant group (normal and with history of RM) compared to non-pregnant women (normal and RM), which is consistent with the increased fibrinogen concentration during pregnancy. No changes were observed in the Darcy constant (Ks) of RM clots, pregnant or not; however, in pregnant control subjects the Ks increased (p = 0.03). The fibrin lysis rate was increased in pregnant women compared to non-pregnant, being faster in women with RM. The rheological properties of the fibrin network in the non-pregnant group (control and RM patients) were similar; in the pregnant state, the fibrin network of the control group was 1.3 times stiffer compared to the control non-pregnant women, and almost unchanged in RM patients. In this study we have found changes in the clot structure that seem to be related to normal pregnancy and an increased rate of the fibrin lysis process in the RM patients, which may have clinical relevance.
Authors:
Rita Marchi; Ysabel López Ramirez; Chandrasekaran Nagaswami; Leona Masova; Anibal Pulido; José López Mora; Aixa Muller; Carmen Luisa Arocha-Piñango; John W Weisel
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  97     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-06-04     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  552-7     Citation Subset:  IM    
Affiliation:
Centro de Medicina Experimental, Laboratorio Biología del Desarollo de la Hemostasia, Instituto Venezolano de Investigaciones Científicas, IVIC Apartado 21827, Caracas, Venezuela. rmarchi@medicina.ivic.ve
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MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / blood,  etiology*
Blood Coagulation Tests
Female
Fibrin / metabolism*,  ultrastructure
Fibrinolysis*
Hemostasis
Humans
Microscopy, Electron, Scanning
Nephelometry and Turbidimetry
Pregnancy
Pregnancy Complications, Hematologic / blood*
Pregnancy Trimester, First*
Thrombelastography
Time Factors
Venezuela
Grant Support
ID/Acronym/Agency:
HL30954/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9001-31-4/Fibrin

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