Document Detail


Haemorrhagic shock and encephalopathy.
MedLine Citation:
PMID:  3732333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two infants are described with a fulminant disorder characterised by profound circulatory collaps and shock, generalised convulsions and unremitting coma, bleeding due to severe DIC, fever, diarrhoea, metabolic acidosis and renal and hepatic failure. Both infants died shortly after onset of the symptoms. Autopsy mainly revealed haemorrhages in different organs, anoxaemic lesions in the brain and a normal structure of liver and pancreas. No causative agent could be demonstrated. We believe that both patients suffered from haemorrhagic shock and encephalopathy, a mostly fatal disorder which has recently been described. Although the clinical and biochemical features are very distinctive, this syndrome is probably heterogeneous and its differentiation from some other disorders may be difficult. Its pathogenesis is unknown but there are some indications that intravascular activity of trypsin may play a role. During a study of the two families we obtained abnormal results of immunologic tests in most members: the interpretation of this finding remains conjectural. Haemorrhagic shock and encephalopathy may occur more frequently than the restricted literature on this subject suggests. Future studies will have to deal with the question of identity and pathogenesis.
Authors:
K J Van Acker; A M Roodhooft; H Van Bever
Related Documents :
2672783 - Symmetrical thalamic degeneration with calcifications of infancy.
11754333 - Localized proton mr spectroscopic detection of nonketotic hyperglycinemia in an infant.
24888273 - Early use of allogeneic hematopoietic stem cell transplantation for infants with mll ge...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  145     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antigen-Antibody Complex / analysis
Brain Diseases / complications*,  immunology,  pathology
Disseminated Intravascular Coagulation / complications,  immunology,  pathology
Female
Humans
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Infant
Male
Parents
Shock, Hemorrhagic / complications*,  immunology,  pathology
Syndrome
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Iron status in low birth weight infants on breast and formula feeding.
Next Document:  Dopamine-beta-hydroxylase in patients with cystic fibrosis.