Document Detail

Haemorrhagic-ischaemic lesions of the neonatal brain: correlation between cerebral visual impairment, neurodevelopmental outcome and MRI in infancy.
MedLine Citation:
PMID:  7530219     Owner:  NLM     Status:  MEDLINE    
The relationship between the degree of cerebral visual impairment, established using the acuity card procedure, and the extent of neurological sequelae was assessed in 65 at-risk neonates in a prospective follow-up study. MRI and CT scans were performed in all infants with severe neurological sequelae. 11 of 12 children with an acuity at or below the 10th centile at 18 months developed cerebral palsy: the underlying condition was extensive cystic leukomalacia in all. An acuity above the 10th centile was no guarantee of normal development, as 10 out of 52 such infants developed cerebral palsy. MRI and CT scans showed that periventricular high signal intensity in the occipital area was a non-specific finding with regard to visual function. Extensive periventricular white matter loss and involvement of the striate/parastriate cortex was found in the most severely visually impaired infants.
P Eken; L S de Vries; Y van der Graaf; L C Meiners; O van Nieuwenhuizen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  37     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-21     Completed Date:  1995-02-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-55     Citation Subset:  IM    
Department of Child Neurology, Whilhelmina Children's Hospital, Utrecht, The Netherlands.
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MeSH Terms
Brain Ischemia / classification,  complications*,  diagnosis,  epidemiology
Case-Control Studies
Cerebral Hemorrhage / classification,  complications*,  diagnosis,  epidemiology
Developmental Disabilities / epidemiology,  etiology*
Follow-Up Studies
Infant, Newborn
Leukomalacia, Periventricular / classification,  complications*,  diagnosis,  epidemiology
Magnetic Resonance Imaging*
Prospective Studies
Severity of Illness Index
Tomography, X-Ray Computed
Ultrasonography, Doppler, Transcranial
Vision Disorders / classification,  diagnosis,  epidemiology,  etiology*
Visual Acuity

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