| Haemorrhage during anaesthesia and surgery: continuous measurement of microcirculatory blood flow in the kidney, liver, skin and skeletal muscle. | |
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MedLine Citation:
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PMID: 7588673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multichannel laser Doppler flowmeters allow continuous, simultaneous measurement of perfusion in several organs. We measured microcirculatory blood flow in the kidney, liver, skin and skeletal muscle in 10 anaesthetized rats subjected to abdominal surgery and graded haemorrhage (withdrawal of 5% total blood volume every 10 min). Mean arterial blood pressure, heart rate and haemoglobin concentrations were also measured. Muscle blood flow decreased after only 10% blood loss, but without significant changes in the other organs. At this time the perfusion signal from the muscle was cycling 2-3 times per min (slow wave flowmotion) which was never seen in any other organ. After 35% blood loss, all organs monitored maintained approximately 70% of initial flow, despite a 45% decrease in mean arterial pressure from 104 +/- 12 to 55 +/- 9 mmHg (mean +/- SD). After 40% blood loss there was a sharp decrease in blood flow in all organs. Haemoglobin concentration decreased from 14.4 +/- 0.8 to 10.8 +/- 1.3 mg dL-1 after 45% blood loss. We conclude that laser Doppler flowmetry is useful for continuous measurement of microcirculatory blood flow in several organs simultaneously during haemorrhagic hypovolaemia. It showed that microcirculatory blood flow in skeletal muscle is particularly sensitive to lesser degrees of blood loss during anaesthesia. Hypovolaemia-induced slow wave flowmotion occurred only in skeletal muscle, which may be linked to fluid mobilization during haemorrhage. |
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Authors:
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D Erni; A Banic; A M Wheatley; G H Sigurdsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 12 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-12-07 Completed Date: 1995-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 423-9 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, University of Berne, Inselspital, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen
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surgery Anesthesia, General* Animals Blood Loss, Surgical / physiopathology* Blood Pressure Blood Volume Fluid Shifts Heart Rate Hemoglobins / analysis Kidney / blood supply* Laser-Doppler Flowmetry Liver / blood supply* Male Microcirculation Monitoring, Intraoperative Muscle, Skeletal / blood supply* Rats Rats, Wistar Regional Blood Flow Shock / physiopathology Skin / blood supply* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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