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Haemopoietic progenitor-cell responses in mice with the transplanted lymphoid leukaemia ABE-8.
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MedLine Citation:
PMID:  313215     Owner:  NLM     Status:  MEDLINE    
BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen. Neutrophil-macrophage progenitors, assayed as granulocyte-macrophage colony-forming cells in agar, increased in number only if invasion of the marrow or spleen by ABE-8 cells was demonstrable. Rises in B-lymphocyte colony-forming cells occurred whether or not there was invasion of the host spleen or marrow. No increase in progenitor cells was found in mice bearing diffusion chambers containing ABE-8 cells. The magnitude of leukaemic infiltration was determined by assaying numbers of leukaemic stem cells in the spleen and marrow using a selective cloning system. This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues.
J H McCarthy
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of cancer     Volume:  40     ISSN:  0007-0920     ISO Abbreviation:  Br. J. Cancer     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-27     Completed Date:  1979-09-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370635     Medline TA:  Br J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  144-51     Citation Subset:  IM    
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MeSH Terms
B-Lymphocytes / physiology
Bone Marrow Cells
Eosinophils / physiology
Hematopoietic Stem Cells / physiology*
Leukemia, Experimental / physiopathology
Leukemia, Lymphoid / pathology,  physiopathology*
Macrophages / physiology
Mice, Inbred BALB C
Neoplasm Transplantation
Neutrophils / physiology
Spleen / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Br J Cancer
ISSN: 0007-0920
ISSN: 1532-1827
Article Information
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Print publication date: Month: 7 Year: 1979
Volume: 40 Issue: 1
First Page: 144 Last Page: 151
ID: 2009970
PubMed Id: 313215

Haemopoietic progenitor-cell responses in mice with the transplanted lymphoid leukaemia ABE-8.
J. H. McCarthy

Article Categories:
  • Research Article

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