| Haemopoietic progenitor-cell responses in mice with the transplanted lymphoid leukaemia ABE-8. | |
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MedLine Citation:
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PMID: 313215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BALB/c mice bearing the transplanted lymphoid tumour ABE-8 developed increased levels of neutrophil, macrophage and eosinophil progenitor cells in the marrow and spleen. Neutrophil-macrophage progenitors, assayed as granulocyte-macrophage colony-forming cells in agar, increased in number only if invasion of the marrow or spleen by ABE-8 cells was demonstrable. Rises in B-lymphocyte colony-forming cells occurred whether or not there was invasion of the host spleen or marrow. No increase in progenitor cells was found in mice bearing diffusion chambers containing ABE-8 cells. The magnitude of leukaemic infiltration was determined by assaying numbers of leukaemic stem cells in the spleen and marrow using a selective cloning system. This transplanted lymphoid leukaemia appears to be a useful model for analysing the effects of haemopoietic tumours on host haemopoietic tissues. |
Authors:
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J H McCarthy |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of cancer Volume: 40 ISSN: 0007-0920 ISO Abbreviation: Br. J. Cancer Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-27 Completed Date: 1979-09-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370635 Medline TA: Br J Cancer Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 144-51 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / physiology Bone Marrow Cells Eosinophils / physiology Female Hematopoiesis Hematopoietic Stem Cells / physiology* Leukemia, Experimental / physiopathology Leukemia, Lymphoid / pathology, physiopathology* Macrophages / physiology Male Mice Mice, Inbred BALB C Neoplasm Transplantation Neutrophils / physiology Spleen / cytology |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Br J Cancer ISSN: 0007-0920 ISSN: 1532-1827 |
Article Information Download PDF  Print publication date: Month: 7 Year: 1979 Volume: 40 Issue: 1 First Page: 144 Last Page: 151 ID: 2009970 PubMed Id: 313215 |
| Haemopoietic progenitor-cell responses in mice with the transplanted lymphoid leukaemia ABE-8. | |
| J. H. McCarthy | |
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