Document Detail

Haemopoietic growth factors for neonates: assessing risks and benefits.
MedLine Citation:
PMID:  15035456     Owner:  NLM     Status:  MEDLINE    
This review summarises the rationale, clinical trial evidence for benefit and potential toxicities of Erythropoietin, Thrombopoietin, Granulocyte Colony Stimulating Factor and Granulocyte-Macrophage Colony Stimulating Factor. Erythropoietin has failed to have a clinical impact on red cell transfusion requirement in very low birth weight infants; it is uncertain whether Thrombopoietin will find a significant clinical role in neonatal thrombocytopenia and there is, as yet, insufficient evidence for the routine use of Granulocyte- or Granulocyte-Macrophage Colony Stimulating Factor to prevent or treat bacterial infection. A number of theoretical risks of haemopoietic growth factor use in neonates have been suggested, but no toxicities have been observed during their clinical use. Exploring the potential for benefit in selected groups of infants should be encouraged.
R Carr; N Modi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992). Supplement     Volume:  93     ISSN:  0803-5326     ISO Abbreviation:  Acta Paediatr Suppl     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-06-17     Revised Date:  2008-05-12    
Medline Journal Info:
Nlm Unique ID:  9315043     Medline TA:  Acta Paediatr Suppl     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Department of Haematology, King's College, Guy's Hospital Campus, London, UK.
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MeSH Terms
Erythropoietin / adverse effects,  therapeutic use
Granulocyte Colony-Stimulating Factor / adverse effects,  therapeutic use
Granulocyte-Macrophage Colony-Stimulating Factor / adverse effects,  therapeutic use
Hematopoietic Cell Growth Factors / adverse effects*,  therapeutic use
Infant, Newborn
Leukemia / chemically induced*
Thrombopoietin / adverse effects,  therapeutic use
Reg. No./Substance:
0/Hematopoietic Cell Growth Factors; 11096-26-7/Erythropoietin; 143011-72-7/Granulocyte Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; 9014-42-0/Thrombopoietin

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