Document Detail


Haemophilusinfluenzae type b conjugate vaccine for preventing pneumonia in infants hospitalized for bronchiolitis: a case-control study.
MedLine Citation:
PMID:  19497772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Haemophilus influenzae type b (Hib) conjugate vaccine reduces the risk of pneumonia in infants. OBJECTIVE: To determine the effect of Hib conjugate vaccine (HibCV) on the prevention of pneumonia as a complication among infants hospitalized for bronchiolitis. METHODS: This record-based case-control study was conducted at The Children's Hospital "Dr. Ovidio Aliaga U" in La Paz, Bolivia during 2003 and 2004. Cases were infants hospitalized for bronchiolitis under 1 year of age who developed radiological pneumonia during hospitalization. Controls were patients who had good clinical progress without the use of antibiotics. Pneumonia was defined by alveolar consolidation on chest X-ray that justified the use of antibiotics. RESULTS: Eighty patients were studied (16 cases and 64 controls). Their median age was 4.5 months. Demographic and clinical features were similar in both groups, except for a higher proportion of vomiting (56.3% vs. 28.1%; p<0.05) in the case group. The percentage of unvaccinated infants was significantly higher in cases (68.8% vs. 26.6%; p<0.05) and the length of hospital stay longer (8.5+/-5.4 vs. 3.1+/-2.2 days; p<0.05). There was a strong association between unvaccinated infants and the occurrence of pneumonia as a complication (odds ratio 6.1, 95% confidence interval 1.8-20.1; p<0.01). CONCLUSIONS: Unvaccinated infants admitted for bronchiolitis have a higher risk of radiologically confirmed pneumonia. Larger studies are needed to validate these results and reconsider the burden of Hib infection among infants in less developed countries.
Authors:
Ariel A Salas; H Jorge Salazar; Victor H Velasco
Publication Detail:
Type:  Journal Article     Date:  2009-06-03
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  14     ISSN:  1878-3511     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e68-72     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Division of General Pediatrics, Clinica Caja Petrolera de Salud, 2525 Arce Ave., PO Box 3943, San Jorge, La Paz, Bolivia. ariel.a.salas@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Bacterial Capsules / administration & dosage*
Bolivia / epidemiology
Bronchiolitis / complications*
Case-Control Studies
Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
Female
Haemophilus Infections / complications,  epidemiology,  prevention & control*
Haemophilus Vaccines / administration & dosage*
Hepatitis B Vaccines / administration & dosage
Hospitalization
Humans
Infant
Male
Pneumonia, Bacterial / complications,  epidemiology,  prevention & control*
Poliovirus Vaccine, Inactivated / administration & dosage
Retrospective Studies
Vaccination*
Vaccines, Combined / administration & dosage
Vaccines, Conjugate / administration & dosage
Chemical
Reg. No./Substance:
0/Bacterial Capsules; 0/DTPa-HBV-IPV combined vaccine; 0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Haemophilus Vaccines; 0/Haemophilus influenzae type b polysaccharide vaccine; 0/Hepatitis B Vaccines; 0/Hiberix; 0/Poliovirus Vaccine, Inactivated; 0/Tritanrix-HepB vaccine; 0/Vaccines, Combined; 0/Vaccines, Conjugate

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