Document Detail


Haemophilia in the first years of life.
MedLine Citation:
PMID:  18510541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Surgery in infants and young children with haemophilia, when preceded by accurate diagnosis and accompanied by safe and effective factor prophylaxis, is not associated with a significant risk of haemorrhage. Haemophilic newborns undergoing circumcision or major surgery prior to diagnosis and in the absence of appropriate haemostatic prophylaxis remain as a concern. Inhibitor development has replaced haemorrhage as the major surgical complication in the developed world, largely because of the intensity of treatment used to secure haemostasis. For that reason only, essential surgery should be performed. Intracranial haemorrhage (ICH) during the neonatal period affects 3.5-4.0% of all haemophilia boys in countries with a good standard of health care, which is considerably (40-80 times) higher than expected in the normal population. Because of the high frequency of sporadic cases, ICH in the neonatal period can only be partially prevented by improved carrier diagnosis and counselling. Infections and thrombosis are the major serious complications of central venous lines. Large differences are seen in the frequency of these complications, the most plausible explanations are probably related to the protocol used for device care, the quality of education and the compliance of the users, an issue addressed in an on-going study.
Authors:
R Ljung; H Chambost; A-M Stain; D DiMichele
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  14 Suppl 3     ISSN:  1365-2516     ISO Abbreviation:  Haemophilia     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-30     Completed Date:  2008-12-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  IM    
Affiliation:
Departments of Paediatric, Lund University, University Hospital, Malmö, Sweden. rolf.ljung@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Catheterization, Central Venous / methods
Child, Preschool
Circumcision, Male / adverse effects
Factor IX / therapeutic use
Factor VIII / therapeutic use
Genetic Testing
Hemarthrosis / complications*,  drug therapy,  surgery
Hemophilia A / complications*,  drug therapy,  surgery
Humans
Infant
Infant, Newborn
Intracranial Hemorrhages / epidemiology,  prevention & control*
Male
Risk Factors
Thrombosis / prevention & control*
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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