Document Detail

Haemophagocytosis in a patient with Crimean Congo haemorrhagic fever.
MedLine Citation:
PMID:  17644726     Owner:  NLM     Status:  MEDLINE    
Crimean-Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements were obtained. The diagnosis was confirmed by detection of IgM antibody to CCHF virus and positive RT-PCR. Although the main pathogenesis of CCHF infection is not elucidated yet, haemophagocytosis, a symptom rarely reported in viral haemorrhagic fevers, was observed in this case. Haemophagocytosis is suggested to have a role in the development of pancytopenia in CCHF, the mechanism of which still needs to be investigated, probably with cytokine studies. Together with clinical symptoms and patient history, haemophagocytosis may be an indicator for CCHF.
Atahan Cagatay; Mahir Kapmaz; Asli Karadeniz; Seniha Basaran; Mustafa Yenerel; Selim Yavuz; Kenan Midilli; Halit Ozsut; Haluk Eraksoy; Semra Calangu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of medical microbiology     Volume:  56     ISSN:  0022-2615     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-23     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1126-8     Citation Subset:  IM    
Department of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Biological Markers
Blood Platelets / immunology
Bone Marrow / physiopathology*
Erythrocytes / immunology
Hemorrhagic Fever Virus, Crimean-Congo / pathogenicity*
Hemorrhagic Fever, Crimean / immunology,  physiopathology*
Histiocytes / immunology*
Neutrophils / immunology
Reg. No./Substance:
0/Biological Markers

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