Document Detail

Haemolytic-uraemic syndrome treated with heparin.
MedLine Citation:
PMID:  5448778     Owner:  NLM     Status:  MEDLINE    
Three children with the haemolytic-uraemic syndrome were treated with intravenous heparin. Peritoneal dialysis was required for two of them, one of whom died after 26 days of therapy. Renal biopsy specimens from the two survivors showed widespread glomerular disease, which appeared permanent in one case, but only occasional thrombi. It is suggested that heparin therapy, by preventing further intrarenal thrombosis, allowed the normal fibrinolytic mechanisms to remove previously formed thrombi.
M W Moncrieff; E F Glasgow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  3     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Jul 
Date Detail:
Created Date:  1970-09-28     Completed Date:  1970-09-28     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  188-91     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Hemolytic / drug therapy*,  pathology
Heparin / administration & dosage,  therapeutic use*
Injections, Intravenous
Kidney / pathology
Kidney Cortex Necrosis / drug therapy,  pathology
Kidney Failure, Acute / drug therapy*,  pathology,  therapy
Kidney Glomerulus / pathology
Peritoneal Dialysis
Thrombocytopenia / drug therapy,  pathology
Reg. No./Substance:

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